Ornella Rossetto Selected Research

Neurotoxins

4/2022	Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody.
1/2022	Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.
1/2021	Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets.
11/2019	Tables of Toxicity of Botulinum and Tetanus Neurotoxins.
11/2019	The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs.
6/2018	Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals.
1/2017	Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.
3/2016	On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments.
1/2013	Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons.
12/2012	Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons.

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Ornella Rossetto Research Topics

Disease

17	Tetanus 04/2022 - 05/2003
16	Botulism 01/2022 - 06/2006
13	Paralysis (Palsy) 01/2021 - 11/2006
5	Pain (Aches) 01/2017 - 04/2006
3	Muscle Spasticity (Spastic) 11/2021 - 12/2012
3	Dystonia (Limb Dystonia) 11/2018 - 08/2002
3	Epilepsy (Aura) 01/2016 - 02/2005
2	Partial Epilepsies (Epilepsy, Partial) 01/2016 - 07/2012
2	Seizures (Absence Seizure) 01/2016 - 02/2005
2	Central Nervous System Diseases (CNS Diseases) 02/2007 - 10/2006
1	Wounds and Injuries (Trauma) 01/2021
1	Movement Disorders (Movement Disorder) 11/2018
1	Nervous System Diseases (Neurological Disorders) 12/2015
1	Facial Pain (Myofacial Pain) 08/2014
1	Ganglion Cysts (Ganglion) 08/2014
1	Atrophy 05/2007

Drug/Important Bio-Agent (IBA)

25	Botulinum Toxins (Botulinum Toxin)IBA 04/2022 - 08/2002
13	NeurotoxinsIBA 04/2022 - 04/2006
10	incobotulinumtoxinA FDA Link 11/2018 - 08/2002
9	Proteins (Proteins, Gene)FDA Link 11/2021 - 06/2006
6	Metalloproteases (Metalloproteinases)IBA 04/2022 - 07/2012
5	SNARE Proteins (SNAREs)IBA 01/2022 - 05/2003
4	tetanospasmin (tentoxilysin)IBA 11/2021 - 07/2012
4	DisulfidesIBA 11/2019 - 11/2011
3	R-SNARE Proteins (Vesicle-Associated Membrane Protein)IBA 04/2022 - 05/2003
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022 - 12/2012
3	Formaldehyde (Formol)FDA Link 11/2021 - 04/2006
3	Type A Botulinum Toxins (Botox)FDA Link 11/2018 - 08/2013
2	Peptides (Polypeptides)IBA 04/2022 - 01/2017
2	ExotoxinsIBA 11/2021 - 11/2019
2	Qa-SNARE Proteins (Syntaxin)IBA 12/2017 - 08/2017
2	ThioredoxinsIBA 09/2014 - 01/2013
2	Thioredoxin-Disulfide ReductaseIBA 09/2014 - 01/2013
1	rimabotulinumtoxinB FDA Link 04/2022
1	Immunoglobulins (Immunoglobulin)IBA 11/2021
1	Hazardous Substances (Hazardous Materials)IBA 07/2021
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021
1	gamma-Aminobutyric Acid (GABA)IBA 01/2021
1	ebselenIBA 11/2019
1	Vesicle-Associated Membrane Protein 2 (VAMP2)IBA 01/2017
1	Scorpion Venoms (Scorpion Venom)IBA 01/2017
1	PlasticsIBA 01/2016
1	Pharmaceutical PreparationsIBA 12/2015
1	Oxidoreductases (Dehydrogenase)IBA 09/2014
1	Analgesics (Analgesic Drugs)IBA 08/2014
1	Capsaicin (Zostrix)FDA Link 08/2014
1	TRPV Cation ChannelsIBA 08/2014
1	botulinum toxin type DIBA 05/2013
1	Tetanus ToxinIBA 12/2012
1	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2012
1	CalciumIBA 03/2009
1	Bacterial ToxinsIBA 02/2007
1	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 11/2006
1	LipidsIBA 11/2006
1	AlbuminsIBA 11/2006
1	Phospholipases A2 (Phospholipase A2)IBA 11/2006
1	LysophospholipidsIBA 11/2006
1	GangliosidesIBA 10/2006
1	Protein Isoforms (Isoforms)IBA 04/2006
1	Anticonvulsants (Antiepileptic Drugs)IBA 02/2005
1	Kainic Acid (Kainate)IBA 02/2005
1	Liposomes (Liposome)IBA 05/2003

Therapy/Procedure

7	Therapeutics 11/2021 - 08/2002
1	Denervation 08/2014
1	Injections 08/2002